| N03A X09 Lamotrigin - N05A H03 Olanzapin |
| ATC1 | N03A X09 Lamotrigin (Lamotrigine) |
| ATC2 | N05A H03 Olanzapin (Olanzapine) |
| Nivå | Akademisk interesse. (les mer...) |
| Konsekvens | Mulig nedsatt konsentrasjon av lamotrigin (20-30 %). Mulig økt konsentrasjon av olanzapin (20-30 %). |
| Mekanisme | Ukjent mekanisme. |
| Grunnlag | Interaksjonsstudier |
| Referanser |
| 1. | Sidhu J, Job S, Bullman J et al. Pharmacokinetics and tolerability of lamotrigine and olanzapine coadministered to healthy subjects. Br J Clin Pharmacol 2006; 61: 420–6. Les mer... |
| 2. | Jann MW, Hon YY, Shamsi SA et al. Lack of pharmacokinetic interaction between lamotrigine and olanzapine in healthy volunteers. Pharmacotherapy 2006; 26: 627–633. Les mer... |
| 3. | Spina E, d’Arrigo C, Migliardi G et al. Effect of adjunctive lamotrigine treatment on the plasma concentrations of clozapine, risperidone and olanzapine in patients with schizophrenia or bipolar disorder. Ther Drug Monit 2006; 28: 599–602. Les mer... |