| H02A B06 Prednisolon - Z0HY Hyperikum |
ATC1 | H02A B06 Prednisolon (Prednisolone) |
ATC2 | Z0HY Hyperikum (Hypericum) |
Nivå | Bør ikke kombineres. (les mer...) |
Konsekvens | Nedsatt konsentrasjon av prednison/prednisolon (ca. 30-60 % i rapporter med de kraftige enzyminduktorene rifampicin/karbamazepin/fenobarbital). |
Håndtering | Legemiddelalternativer: Det kan være det enkleste å seponere johannesurt. Eventuelt kan oppstart med et annet antidepressivt legemiddel, for eksempel et SSRI-preparat, vurderes. Observer at det tar 1-2 uker fra johannesurt seponeres til interaksjonseffekten er borte. |
Mekanisme | Økt metabolisme av prednison/prednisolon via CYP3A4. |
Grunnlag | Indirekte data |
Referanser |
1. | McAllister WAC, Thompson PJ, Al-Habet SM et al. Rifampicin reduces effectiveness and bioavailability of prednisolone. BMJ 1983; 286: 923–5. Les mer... |
2. | Carrie F, Roblot P, Bouquet S et al. Rifampin-induced nonresponsiveness of giant cell arteritis to prednisone treatment. Arch Intern Med 1994 154 1521–4. Les mer... |
3. | Bergrem H, Refvem OK. Altered prednisolone pharmacokinetics in patients treated with rifampicin. Acta Med Scand 1983; 213: 339–43. Les mer... |
4. | Olivesi A. Modified elimination of prednisolone in epileptic patients on carbamazepine monotherapy, and in women using low-dose oral contraceptives. Biomed Pharmacother 1986; 40: 301–8. Les mer... |
5. | Bartoszek M, Brenner AM, Szefler SJ. Prednisolone and methylprednisolone kinetics in children receiving anticonvulsant therapy. Clin Pharmacol Ther; 1987; 42: 424–32. Les mer... |
6. | Sato A, Katada S, Sato M, Kobayashi H. A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine. No To Shinkei 2004; 56: 61–3. Les mer... |
7. | Gambertoglio JG, Holford NHG, Kapusnik JE et al. Disposition of total and unbound prednisolone in renal transplant patients receiving anticonvulsants. Kidney Int 1984; 25: 119–23. Les mer... |
8. | Brooks PM, Buchanan WW, Grove M et al. Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study. Ann Rheum Dis 1976; 35: 339–43. Les mer... |